Other differential diagnoses of pigmented lesion of the mouth consist of smokers melanosis, Addisons disease, blue nevi, Albright syndrome, foreign bodies, Peutz-Jeghers syndrome, drug-induced pigmentation, and Laugier-Hunziker syndrome (4)
NO most of the time we can find a way to calm down inflammation It is ok to use very powerful short-term immunosuppression IMPACT-Crohn study target both immune system and microbiome after achieving remission Steroids to induce clinical remission (n = 8 with FMT and n = 9 with sham = pilot study) randomised to single FMT or sham FMT via colonoscopy Follow-up study ongoing in CD as a relay after TNF withdrawal Conclusions: Need for a paradigm shift regarding drug positioning In IBD context: distinguish treatment for induction and maintenance Keep in mind the nature of microbiome-based drugs = not brutal immunosuppressant IBD Treatment Paradigms: past, present and future by David Rubin @IBDMD #DDW2025 What is a treatment paradigm
Medications such as semaglutide and tirzepatide affect appetite hormones, digestion, and blood sugar regulation
Its not ideal for systemic injuries but may still offer digestive support
Oxidative stress promotes specific protein damage in saccharomyces cerevisiae
cAMP, Cyclic Adenosine Monophosphate